EARS -Otitis Media - Acute (Moraxella catarrhalis, influenzaeHaemophilus, Streptococcus pneumoniae}

Note: In one third of cases no bacterial pathogen is identified. Benefits of antibiotic therapy in question. (AOM Tx Duration: If <2 years × 10 days. If ≥2 years × 5-7 days. See Pediatr Infect Dis J 1999;18:1-9.)

 

Amoxicillin - Drug of choice, especially if no antibiotics used in previous 30 days. If clinical failure on day 3, use alternative beta-lactam listed.

 

(Amoxil®, Trimox®)

Generics available

Pregnancy: B; Lactation: Safe

 

Caps: 250 mg, 500 mg

Tabs: 500 mg, 875 mg

Chewable Tabs: 125 mg, 250 mg

Oral Susp: 50 mg/mL, 125 mg/5 mL,

 

 

Children: Dosing: 40-90 mg/kg/day (max 1500 mg/day) in divided doses three times daily.

If <2 years 10 days. If ≥2 years 5-7 × days.

 

125 mg/5 mL at 40 mg/kg/day or

250 mg/5 mL at 80 mg/kg/day

 

8 kg (18 lb) = 1 tsp (5 mL) Q8H

13 kg (29 lb) = 1½ tsp (7.5 mL) Q8H

17 kg (37 lb) = 2 tsp (10 mL) Q8H

21 kg (46 lb) = 2½ tsp (12.5 mL) (NTE 500 mg) Q8H

25 kg (55 lb) = 3 tsp (15 mL) (NTE

500 mg) Q8H

 

Adult: 875 mg twice daily or 500 mg three times daily for 5-10 days.

 

 

 

Food: May take with or without meals.

Important side effects: Diarrhea and nausea. May cause nonallergic maculopapular rash.

 

Reduce dose in renal disease (CrCl <30 mL/min).

 

Amoxicillin/clavulanate

(Augmentin®)

Pregnancy: B; Lactation: Unk

 

Q12H Formulations (7:1):

Tabs: 875 mg/125 mg

 

Chewable Tabs:

200 mg/28.5 mg, 400 mg/57 mg

 

Oral Susp:

200 mg/28.5 mg/5 mL,

400 mg/57 mg/5 mL

 

Augmentin ES-600 Powder for Oral Suspension (14:1): 600 mg/42.9 mg/ 5 mL

.

 

Children: 80-90 mg amoxicillin component/kg/day (max 1600 mg/day) in divided doses two times daily. If <2 years × 10 days. If ≥2 years × 5-7 days.

14:1 (ES-600) formulation is advised, especially if antibiotic exposure for otitis media in preceding 3 months and either age ≤2 years or daycare attendance. If low likelihood of resistant S. pneumoniae, may use 7:1 formulation; however, limit clavulanate to no more than 10 mg/kg/day (amoxicillin 70 mg/kg/day).

 

Q12H using 600/5 mL susp @ 90 mg/kg/day

8 kg (18 lb) = 3 mL Q12H

12 kg (26 lb) = 4.5 mL Q12H

16 kg (35 lb) = 6 mL Q12H

20 kg (44 lb) = 7.5 mL Q12H

24 kg (53 lb) = 9.0 mL Q12H

28 kg (62 lb) = 10.5 mL Q12H

32 kg (70 lb) = 12.0 mL Q12H

36 kg (79 lb) = 13.5 mL Q12H

>40 kg = Experience not available.

If low likelihood of resistant S. pneumoniae, may use 7:1 formulation; however, limit clavulanate to no more than 10 mg/kg/day (amoxicillin 70 mg/kg/day).

 

Q12H using 400 mg/57 mg/5 mL

suspension @ 70 mg/kg/day:

11 kg (24 lb) = 1 tsp (5 mL) Q12H

17 kg (37 lb) = 1½ (7.5 mL) tsp Q12H

23 kg (51 lb) = 2 tsp (10 mL) Q12H

>23 kg = Use adult dose.

Adult: 500-875 mg twice daily for 10 days.

 

Food: Take with food to reduce diarrhea.

 

Important side effects: Diarrhea (common), nausea, rash. May cause nonallergic maculopapular rash.

 

 

 

 

 

 

 

Use with caution in hepatic disease.

Reduce dose if renal impairment

(CrCl <30 mL/min).

 

Cefpodoxime

(Vantin®)

Pregnancy: B; Lactation: Unsafe

 

Tabs: 100 mg, 200 mg

Oral Susp: 50 mg/5 mL,

100 mg/5 mL

 

 

Children >2 months to 12 years: 10 mg/kg/day (NTE 400 mg) in divided doses once or twice daily. If <2 years × 10 days. If ≥2 years × 5-7 days.

 

100 mg/5 mL @ 10 mg/kg/day

10 kg (22 lb) = 1 tsp (5 mL) Q24H

20 kg (44 lb) = 2 tsp (10 mL) Q24H

30 kg (66 lb) = 3 tsp Q24H

 

Adult: 100-200 mg PO twice daily for 5-7 days.

 

 

Food: Take tablets with food.

Suspension may be taken without regard to food.

 

Important side effects: Diarrhea.

 

Cefuroxime axetil

(Ceftin®)

Pregnancy: B; Lactation: Unsafe

 

Tabs: 125 mg, 250 mg, 500 mg

 

Oral Susp: 125 mg/5 mL,

250 mg/5 mL

 

 

Children >3 months to 12 years:

30 mg/kg/day (NTE 1,000 mg/day) in divided doses twice daily. If <2 years × 10 days. If ≥ 2 years × 5-7 days.

 

125 mg/5 mL @ 30 mg/kg/day

8 kg (18 lb) = 1 tsp (5 mL) Q12H

12.5 kg (27 lb) = 1½ tsp (7.5 mL) Q12H

17 kg (37 lb) = 2 tsp (10 mL) Q12H

25 kg (55 lb) = 1 tbsp Q12H

33 kg (73 lb) = Use adult dose.

Adult: 250-500 mg PO twice daily for 5-7 days.

 

 

Food: Take suspension with food.

Tablets may be taken without regard to food.

 

Important side effects: Nausea, vomiting, diarrhea.

 

Trimethoprim/Sulfamethoxazole*

Alternative for beta-lactam intolerance.

(Bactrim®, Septra®)

 

Children >2 months: 8-10 mg/kg/day TMP component (max 320 mg/day) in divided doses twice daily for 5-10 days.

 

Food: May take without regard to food. Encourage fluids.

Generics available

Pregnancy: C; Lactation: Unsafe

 

Single Strength (SS) Tabs:

80 mg/400 mg

 

Double Strength (DS) Tabs:

160 mg/800 mg

 

Oral Susp: 40 mg/200 mg per 5 mL

 

May be less active against penicillin resistant S. pneumoniae.

 

8-10 mg/kg/day @ 40 mg/200 mg/5 mL

 

10 kg (22 lb) = 1 tsp (5 mL) Q12H

20 kg (44 lb) = 2 tsp (10 mL) or 1 SS tab Q12H

30 kg (66 lb) = 3 tsp (15 mL) or 1½ SS tab Q12H

40 kg (88 lb) = 4 tsp (20 mL) or 2 SS tabs or 1 DS tab Q12H

 

Adult: 1 DS tab PO twice daily for

5-10 days.

Important side effects: Photosensitivity, rash.

 

EARS - Otitis Media - Failed Treatment

 

 

Levofloxacin*

(Levaquin®)

Pregnancy: C; Lactation: Unsafe

Tabs: 250 mg, 500 mg - >$$$$

 

Adult: 500 mg PO once daily for

10-14 days.

 

Food: With or without meals. Do not take within 2 hours of antacids, magnesium, calcium supplements, zinc, aluminum, sucralfate, vitamins, or minerals (iron or zinc).

 

Important side effects: Photosensitivity, dizziness.

 

Reduce dose if renal impairment

(CrCl <50 mL/min).

 

 

Ceftriaxone

(Rocephin®)

Pregnancy: B; Lactation: Unk

 

Vials: 250 mg, 500 mg, 1,000 mg 1 g - $$$

 

Children and Adult: 50 mg/kg (max 1 g) IM daily × 1-3 days.